Yonghong   Zhang

Assistant Professor  

Office: ESCNE 4.620
Phone: (956) 665-2288
Email: yonghong.zhang@utrgv.edu
Website: https://sites.google.com/site/theyzhanglab

Dr. Yonghong Zhang

Yonghong Zhang received his PhD in radiophysics. With his multidisciplinary education and training background but emphasizing protein NMR, his research interests focus on the elucidation of structure-function relationships of proteins involved in biological processes.





Selected Publications


  • D Chowdhury, M Turner, T Patriarchi, A Hergarden, D Anderson, Y Zhang, J Sun, C Chen, J Ames, and J Hell. "Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down.," EMBO J 37, no. 1 (January (1st Quarter/Winter) 2018): 122.

  • Benxu Cheng, Lisa Morales, Yonghong Zhang, Shizue Mito, and Andrew Tsin. "Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line ," PLoS ONE 12, no. 9 (September 2017): e0184324.

  • Zhigang Li, Yonghong Zhang, Andrew Hedman, James Ames, and David Sacks. "Calmodulin Lobes Facilitate Dimerization and Activation of Estrogen Receptor-α," Journal of Biological Chemistry 292, (March 2017): 4614-4622.

  • Y Hu, A Bernal, James Bullard, and Yonghong Zhang. "Solution structure of protein synthesis initiation factor 1 from Pseudomonas aeruginosa.," Protein science : a publication of the Protein Society 25, no. 12 (December 2016): 2290-2296.

  • Libo Li, Yue Ma, Wentao Wang, Yanping Xu, Jun You, and Yonghong Zhang. "A thermal and electrochemical properties research on gel polymer electrolyte membrane of lithium ion battery," Elsevier: Journal of Physics and Chemistry of Solids 99, (August 2016): 159-166.

  • A Bernal, Y Hu, S Palmer, Alfred Silva, James Bullard, and Yonghong Zhang. "1H, 13C and 15N resonance assignments and secondary structure analysis of translation initiation factor 1 from Pseudomonas aeruginosa.," Biomolecular NMR assignments (March 2016).

  • W Xiao, Yonghong Zhang, L Meza, H Tseng, Y Takada, J Ames, and K Lam. "Optimization of RGD-Containing Cyclic Peptides against αvβ3 Integrin.," Molecular cancer therapeutics 15, no. 2 (February 2016): 232-40.

  • M Turner, Yonghong Zhang, H Carlson, H Stadler, and J Ames. "Chemical shift assignments of mouse HOXD13 DNA binding domain bound to duplex DNA.," Biomolecular NMR assignments 9, no. 2 (November 2015): 267-70.

  • Yonghong Zhang, L Matt, T Patriarchi, Z Malik, D Chowdhury, D Park, A Renieri, J Ames, and J Hell. "Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release.," Heidelberg : The EMBO journal 33, no. 12 (June 2014): 1341-53.

  • J Meng, Y Li , C Camarillo, Y Yao, Yonghong Zhang, Chun Xu, and L Jiang. "The anti-tumor histone deacetylase inhibitor SAHA and the natural flavonoid curcumin exhibit synergistic neuroprotection against amyloid-beta toxicity.," PloS one 9, no. 1 (January (1st Quarter/Winter) 2014): e85570.



Selected Grants and Fellowships


  • Yonghong Zhang. Bacterial Protein Synthesis as a Target for Novel Antibacterial Agents, The Office of Research, Innovation, & Economic Development, $20,000.00 (January 2017 - August 2018)

  • Aaron Silva. Studies on Structure-Activity Relationship of Two Cyclic Peptides-LXW7 and LXW64 Against Tumor Target-avb3 Integrin, The Office of Engaged Scholarship & Learning , $2,000.00 (June 2017 - August 2017)

  • Aaron Silva. Studies on Structure-Activity Relationship of Two Cyclic Peptides-LXW7 and LXW64 Against Tumor Target-avb3 Integrin, The Office of Engaged Scholarship & Learning , $2,000.00 (June 2016 - August 2016)

  • Yonghong Zhang. Determine structure of translation initiation factor 1 from Pseudomonas aeruginosa and its interaction with the 30 ribosomal subunit for new antibiotic development , The Office of Research (FRC), $5,000.00 (January 2016 - August 2016)

  • Yonghong Zhang. Structural Studies of the N-terminus of PSD-95 and its regulation at postsynapses, The Office of Research (FRC), $5,000.00 (January 2015 - August 2015)



Selected Presentations


  • Aaron Silva and Yonghong Zhang. "Structure-activity relationship of new RGD-containing cyclic peptides against avb3 integrin," The 60th Experimental Nuclear Magnetic Resonance Conference, The University of Texas Rio Grande Valley, Pacific Grove, California (April 2019)

  • Mark Abad and Yonghong Zhang. "Structural insight into IF1-initiated translation factor in Clostridium difficile," The 59th Annual UTRGV Rio Grande Valley Regional Science and Engineering Fair, The University of Texas Rio Grande Valley, Brownsville, TX (February 2019)

  • Aaron Silva and Yonghong Zhang. "Structure-Activity Relationship of New RGD-Containing Cyclic Octapeptides Against αvβ3 Integrin," SOUTHWEST THEORETICAL & COMPUTATIONAL CHEMISTRY 2018, The University of Texas Rio Grande Valley, Edinburg, TX (October 2018)

  • Sara Doty, Faith Aguilar, and Yonghong Zhang. "CONSTRUCTION, EXPRESSION, PURIFICATION, AND STRUCTURAL STUDIES OF RECOMBINANT INITIATION FACTOR 3 IN CLOSTRIDIUM DIFFICILE PROTEIN SYNTHESIS," The UTRGV SoM 2nd Annual Research Symposium 2018, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX (September 2018)

  • Frank Mendiola and Yonghong Zhang. "PROTEIN STRUCTURE OF PSEUDOMONAS AERUGINOSA INITIATION FACTOR III," The UTRGV SoM 2nd Annual Research Symposium 2018, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX (September 2018)

  • Yonghong Zhang and James Bullard. "STRUCTURAL UNIQUENESS AND SPECIFIC RECOGNITION OF TRANSLATION INITIATION FACTOR 1 TO THE 30S RIBOSOMAL SUBUNIT IN PSEUDOMONAS AERUGINOSA PROTEIN SYNTHESIS," The Protein Society's 32nd Annual Symposium, The Protein Society, Boston, MA (July 2018)

  • Sara Doty, Faith Aguilar, and Yonghong Zhang. "Recombinant expression and purification of Pseudomonas aeruginosa initiation factor IF-3 for structural studies," The UTRGV CoS Annual Conference 2018, College of Sciences, University of Texas Rio Grande Valley, Edinburg, TX (April 2018)

  • Sara Doty and Yonghong Zhang. "Structure determination of protein synthesis initiation factor 3 from Pseudomonas aeruginosa," The 58th Annual UTRGV Rio Grande Valley Regional Science and Engineering Fair, The University of Texas Rio Grande Valley, Brownsville, TX (February 2018)

  • Yonghong Zhang "Structural and molecular mechanisms of Ca2+-mediated activation of estrogen receptor-alpha by calmodulin," The 2017 CPRIT INNOVATIONS IN CANCER PREVENTION AND RESEARCH CONFERENCE, Cancer Prevention & Research Institute of Texas (CPRIT), Austin, TX (November 2017)

  • Faith Aguilar and Yonghong Zhang. "NMR structural studies on C difficile translation initiation factor 1 ," The UT Austin Symposium for Undergraduate Research Exploration 2017, UT Austin's College of Natural Sciences (SURE in CNS), Austin, TX (September 2017)

Current Courses

CHEM 4306 01I - Special Topics in Biochemistry:
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CHEM 4306 02I - Special Topics in Biochemistry:
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CHEM 4201 01 - Chemistry Problems I:
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CHEM 6380 01I - Sp Top in Biochemistry:
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UNIV 4000 11 - Directed Research:
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CHEM 3303 01I - Biochemistry I:
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CHEM 4325 01 - Chemistry Internship:
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CHEM 3303 02 - Biochemistry I:
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CHEM 3303 03 - Biochemistry I:
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CHEM 3103 01 - Biochemistry I Lab:
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CHEM 3103 03 - Biochemistry I Lab:
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CHEM 3103 05 - Biochemistry I Lab:
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CHEM 3303 02I - Biochemistry I:
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CHEM 6380 02I - Sp Top in Biochemistry:
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CHEM 4202 01 - Chemistry Problems II:
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CHEM 3103 02 - Biochemistry I Lab:
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UNIV 4000 11 - Directed Research:
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Previous Courses