Mark   Z.  Kos

Assistant Professor of Research  

Phone: (210) 585-9772
Email: mark.kos@utrgv.edu

Dr. Mark Z. Kos

My research interests are predominantly in statistical genetics, epidemiology, and the genetics of complex traits, with a focus on psychiatric disorders (e.g., schizophrenia, alcoholism) and brain-related endophenotypes.

  • Areas of Expertise

    • Genetic epidemiology
    • Psychiatric disease
    • Complex disease genetics
  • Education

    • PhD, Biological Anthropology, University of Kansas, 2008
    • MA, Anthropology, University of Kansas, 2006




Selected Publications


  • Rector Arya, Agustin Escalante, Vidya Farook, Jose Restrepo, Daniel Battafarano, Marcio Almeida, Mark Kos, Marcel Fourcaudot, Srinivas Mummidi, Satish Kumar, Joanne Curran, Christopher Jenkinson, John Blangero, Ravindranath Duggirala, and Inmaculada del Rincon. "A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis," Atherosclerosis 271, (April (2nd Quarter/Spring) 2018): 92-101.

  • Rector Arya, Agustin Escalante, Vidya Farook, Jose Restrepo, Daniel Battafarano, Marcio Almeida, Mark Kos, Marcel Fourcaudot, Srinivas Mummidi, Satish Kumar, Joanne Curran, Christopher Jenkinson, John Blangero, Ravindranath Duggirala, and Inmaculada del Rincon. "Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects," Data in Brief 17, (April (2nd Quarter/Spring) 2018): 820-829.

  • Laura Mathies, Fazil Aliev, Andrew Davies, Danielle Dick, Jill Bettinger, B. Porjesz, V. Hesselbrock, H. Edenberg, L. Bierut, J. Nurnberger, T. Foroud, S. Kuperman, J. Kramer, B. Porjesz, L. Bierut, J. Rice, K. Bucholz, A. Agrawal, M. Schuckit, J. Tischfield, A. Brooks, L. Almasy, A. Goate, R. Taylor, L. Bauer, J. McClintick, L. Wetherill, X. Xuei, Y. Liu, D. Lai, S. O'Connor, M. Plawecki, S. Lourens, G. Chan, J. Meyers, D. Chorlian, C. Kamarajan, A. Pandey, Jing Zhang, J. Wang, M. Kapoor, S. Bertelsen, A. Anokhin, V. McCutcheon, S. Saccone, J. Salvatore, B. Cho, Mark Kos, A. Parsian, and M. Reilly. "Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations," Alcoholism: Clinical and Experimental Research 41, no. 12 (December 2017): 2033-2040.

  • Mark Kos, M Carless, J Peralta, Joanne Curran, E Quillen, M Almeida, A Blackburn, L Blondell, D Roalf, M Pogue-Geile, R Gur, Harald Goring, V Nimgaonkar, R Gur, and L Almasy. "Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.," American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (September 2017).

  • Mark Kos, M Carless, J Peralta, A Blackburn, M Almeida, D Roalf, M Pogue-Geile, K Prasad, R Gur, V Nimgaonkar, Joanne Curran, Ravindranath Duggirala, D Glahn, John Blangero, R Gur, and L Almasy. "Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk.," Schizophrenia bulletin 42, no. 2 (March 2016): 288-300.

  • L Almasy, Mark Kos, and John Blangero. "Localizing the genes that shape human variation," Genome Mapping and Genomics in Human and Non-Human Primates. 2015.

  • Hemant Kulkarni, Mark Kos, J Neary, Thomas Dyer, J Kent, Jr, Harald Goring, S Cole, A Comuzzie, L Almasy, Michael Mahaney, Joanne Curran, John Blangero, and M Carless. "Novel epigenetic determinants of type 2 diabetes in Mexican-American families.," Human molecular genetics 24, no. 18 (September 2015): 5330-44.

  • J Yan, F Aliev, B Webb, K Kendler, V Williamson, H Edenberg, A Agrawal, Mark Kos, L Almasy, J Nurnberger, Jr, M Schuckit, J Kramer, J Rice, S Kuperman, A Goate, J Tischfield, B Porjesz, and D Dick. "Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence.," Addiction biology 19, no. 4 (July (3rd Quarter/Summer) 2014): 708-21.

  • Mark Kos, D Glahn, M Carless, R Olvera, D McKay, E Quillen, J Gelernter, X Chen, H Deng, J Kent, Thomas Dyer, Harald Goring, Joanne Curran, Ravindranath Duggirala, John Blangero, and L Almasy. "Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders.," American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 165B, no. 4 (June 2014): 294-302.

  • M Carless, Hemant Kulkarni, Mark Kos, J Charlesworth, J Peralta, Harald Goring, Joanne Curran, L Almasy, Thomas Dyer, A Comuzzie, Michael Mahaney, and John Blangero. "Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans.," PloS one 8, no. 9 (September 2013): e73950.



Selected Grants and Fellowships


  • Mark Kos. A Neurobehavioral Family Study of Schizophrenia, NIH/NIMH, (April 1, 2000 - December 31, 2018)

  • Mark Kos. Collaborative Study on the Genetics of Alcoholism, NIH/NIAAA (Res. Found. State Univ. of N.Y. SUNY), (December 31, 2014 - August 31, 2016)



Selected Presentations


  • Mark Kos, J Duan, A Sanders, W Moy, J Freda, E Drigalenko, D He, P Gejman, and Harald Goring. "Dopamine-induced gene expression signatures of schizophrenia in lymphoblastoid cell lines," 1st UTRGV Research Symposium, Edinburg, TX (2017)

  • Mark Kos. "Investigation of the P300 genetic component in the risk of alcohol dependence among European- and African-American subjects via multimarker scoring.," 39th Annual Scientific Meeting of the Research Society on Alcoholism, Research Society on Alcoholism, New Orleans (June 2016)

  • Mark Kos. "Multimarker scoring routines based on P300 neuroelectrical measurements show association with alcohol dependence in independent subjects, with significant enrichment in axon guidance pathways.," 23rd World Congress of Psychiatric Genetics, International Society of Psychiatric Genetics, Toronto, Canada (October 2015)

  • Mark Kos, M Carless, J Peralta, M Almeida, R Gur, M Pogue-Geile, D Roalf, V Nimgaonkar, Joanne Curran, Ravindranath Duggirala, D Glahn, John Blangero, R Gur, and L Almasy. "Exome sequence data from multigenerational families implicate AMPA receptor trafficking in neurocognitive impairment and schizophrenia risk.," 22nd World Congress of Psychiatric Genetics, Copenhagen, Denmark (2014)

  • Mark Kos, A Blackburn, and L Almasy. "Assessment of Type I error rates and power for pathway analysis in family-based samples: Comparison of GWAS and exome sequence datasets from GAW19.," Genetic Analysis Workshop 19, Vienna, Austria (2014)

  • Mark Kos, J Peralta, M Carless, M Almeida, R Gur, M Pogue-Geile, M Calkins, V Nimgaonkar, R Gur, and L Almasy. "Dissection of QTL for neurocognitive performance on chromosome 5q: Identification of two schizophrenia susceptibility loci from exome sequence data.," 21st World Congress of Psychiatric Genetics, Boston, MA (2013)

  • Mark Kos, J Peralta, M Carless, M Almeida, R Gur, M Pogue-Geile, D Roalf, V Nimgaonkar, R Gur, and L Almasy. "Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci involved in fatty acid oxidation.," 63rd American Society of Human Genetics, Boston, MA (2013)

  • Mark Kos, D Glahn, M Carless, R Olvera, J Kent, Thomas Dyer, Harald Goring, Joanne Curran, Ravindranath Duggirala, John Blangero, and L Almasy. "Novel quantitative trait locus for an alcoholism-related phenotype.," 20th World Congress of Psychiatric Genetics, Hamburg, Germany (2012)

  • Mark Kos, M Carless, J Peralta, E Quillen, R Gur, M Pogue-Geile, K Prasad, John Blangero, V Nimgaonkar, R Gur, and L Almasy. "Exome sequencing of multiplex, schizophrenic families implicates variants from chromosome 5q in neurocognitive performance.," 62nd American Society of Human Genetics, San Francisco, CA (2012)

  • Mark Kos, J Neary, D Cruz, H Kulkarni, Joanne Curran, L Almasy, R Olvera, Ravindranath Duggirala, P Thompson, D Glahn, John Blangero, and M Carless. "Association of microRNA expression with diagnoses of major depression (MDD) and the Beck Depression Inventory (BDI) test.," 9th GeneMappers, Port Douglas, Australia (2012)