Evangelia   Kotsikorou

Assistant Professor  

Office: ESCNE 3.364
Phone: (956) 665-2851
Email: evangelia.kotsikorou@utrgv.edu

Dr. Evangelia Kotsikorou





Selected Publications


  • M Meza-AviƱa, M Lingerfelt, L Console-Bram, T Gamage, H Sharir, K Gettys, D Hurst, Evangelia Kotsikorou, D Shore, M Caron, N Rao, L Barak, M Abood, P Reggio, and M Croatt. "Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.," Bioorganic & medicinal chemistry letters 26, no. 7 (April (2nd Quarter/Spring) 2016): 1827-30.

  • P Zhao, T Lane, H Gao, D Hurst, Evangelia Kotsikorou, L Le , E Brailoiu, P Reggio, and M Abood. "Crucial positively charged residues for ligand activation of the GPR35 receptor.," The Journal of Biological Chemistry 289, no. 6 (February 2014): 3625-38.

  • Evangelia Kotsikorou, H Sharir, D Shore, D Hurst, D Lynch, K Madrigal, S Heynen-Genel, L Milan, T Chung, H Seltzman, Y Bai, M Caron, L Barak, M Croatt, M Abood, and P Reggio. "Identification of the GPR55 Antagonist Binding Site Using a Novel Set of High-potency GPR55 Selective Ligands.," Biochemistry 52, no. 52 (December 2013): 9456-69.

  • Evangelia Kotsikorou, F Navas, 3rd, M Roche, A Gilliam, B Thomas, H Seltzman, P Kumar, Z Song, D Hurst, D Lynch, and P Reggio. "The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).," Journal of Medicinal Chemistry 56, no. 17 (September 2013): 6593-612.

  • Evangelia Kotsikorou and P. H. Reggio. "Overview of Non-Cannabinoid Receptors: Chemistry and Modeling," New York, NY: CANNABINOIDS: Actions at Non-CB1/CB2 Cannabinoid Receptors./Springer Publishing Company, 2012.

  • Evangelia Kotsikorou, K. E. Madrigal, D. P. Hurst, H. Sharir, D. L. Lynch, S. Heynen-Genel, L. B. Milan, T. D. Chung, H. H. Seltzman, Y. Bai, M. G. Caron, L. Barak, M. E. Abood, and P. H. Reggio. "Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-potency GPR55 Selective Ligands," Biochemistry 50, (2011): 5633-5647.

  • Evangelia Kotsikorou, D. L. Lynch, M. E. Abood, and P. H. Reggio. "Lipid Molecular Dynamics Simulations Reveal Unique Conformations Associated with Lipid-derived Agonists of the Putative Cannabinoid Receptor GPR55," Chem. Phys. Lipids 164, (2011): 131-143.

  • H. A. Iliff, D. L. Lynch, Evangelia Kotsikorou, and P. H. Reggio. "Parameterization of Org27569: An Allosteric Modulator of the Cannabinoid CB1 G Protein-coupled Receptor," J. Comp. Chem. 32, (2011): 2119-2126.

  • H. Fan, Evangelia Kotsikorou, A. F. Hoffman, H. T. Ravert, D. Holt, D. P. Hurst, C. R. Lupica, P. H. Regggio, R. F. Dannals, and A. G. Horti. "Analogs of JHU75528, a PET Ligand for Imaging of Cerebral Cannabinoid Receptors (CB1): Development of Ligands with Optimized Lipophilicity and Binding Affinity," Eur. J. Med. Chem. 44, (2009): 593-608.

  • Y. Chen, C. Chen, Evangelia Kotsikorou, D. L. Lynch, P. H. Reggio, and P. Y. Liu-Chen. "GEC1-{kappa} Opioid Receptor Binding Involves Hydrophobic Interactions: GEC1 has chaperone-like effect," J. Biol. Chem. 284, (2009): 1673-1685.



Selected Grants and Fellowships


  • Jeffrey Evanseck. Duquesne University - REU Site: Discovery by Computation, Theory and Experiment, National Science Foundation, $303,768.00 (May 1, 2017 - April 30, 2020)

  • Evangelia Kotsikorou. Endocrine Disrupting Effect of DDT and its Analogs on the Androgen Receptor, UTRGV HHMI Program, $2,500.00 (January 16, 2017 - August 20, 2017)

  • Evangelia Kotsikorou. Docking Studies of Novel GPR119 Receptor Agonists - Part 2, Pramana Pharmaceuticals Inc., $4,000.00 (September 1, 2016 - December 31, 2016)

  • Evangelia Kotsikorou. Docking Studies of Novel GPR119 Receptor Agonists - Part 1, Pramana Pharmaceuticals Inc., $4,000.00 (August 1, 2016 - August 31, 2016)

  • Evangelia Kotsikorou. Mutational Study of The GPR119 Receptor, UTPA STEM ADVANCE Graduate Student Support, $8,333.00 (January 16, 2015 - August 20, 2015)

  • Evangelia Kotsikorou. Molecular Modeling of Mouse GPR119 Receptor, UTPA Undergraduate Research Initiative, $2,000.00 (January 16, 2014 - May 15, 2014)

  • Evangelia Kotsikorou. Exploring the binding site of the G protein-coupled receptor GPR119 model using a Pair of Diastereomers with opposing action, UTPA Junior Faculty Travel Support Program, $500.00 (February 15, 2014 - February 19, 2014)

  • Evangelia Kotsikorou. Modeling of GPR119 Receptor and Its Ligands, UTPA STEM ADVANCE Graduate Student Support, $8,333.00 (January 15, 2013 - August 20, 2013)



Selected Presentations


  • Evangelia Kotsikorou, Brenda Ortiz, and Frank Dean. "Molecular Modeling of the Estrogen Receptor Binding Function 3 Interactions with DiethylStilbestrol, Tamoxifen, and Its Analogues," 2017 ACS Southwest Regional Meeting, American Chemical Society, Lubbock, TX (October 2017)

  • Evangelia Kotsikorou, Matthew Rosales, and Sarah Kowalski. "Molecular Modeling of the GPR119 Receptor Binding Site: A Search of the Main Receptor Interactions with AR231453," 2017 ACS Southwest Regional Meeting, American Chemical Society, Lubbock, TX (October 2017)

  • Sarah Kowalski and Evangelia Kotsikorou. "Exploring the Binding Site of GPR119 Receptor Inverse Agonists," 253rd ACS Annual Meeting & Exposition, American Chemical Society, San Francisco, CA (April 2017)

  • Matthew Rosales and Evangelia Kotsikorou. "Docking Study of an Agonist and Inverse Agonist in the GPR119 Receptor," College of Sciences Annual Conference, University of Texas Rio Grande Valley, Edinburg, TX (March 2017)

  • Brenda Ortiz and Evangelia Kotsikorou. "Effects of Diethylstilbestrol on the Estrogen Receptor," College of Sciences Annual Conference, University of Texas Rio Grande Valley, Edinburg, TX (March 2017)

  • Ahyssa Cruz and Evangelia Kotsikorou. "Endocrine Disrupting Chemicals and their Effects on Androgen Receptors," College of Sciences Annual Conference, University of Texas Rio Grande Valley, Edinburg, TX (March 2017)

  • Tevin Luna and Evangelia Kotsikorou. "A Potential New Antibiotic Against P. Aeruginosa," College of Sciences Research Conference , University of Texas San Antonio, San Antonio, TX (October 2016)

  • Sarah Kowalski and Evangelia Kotsikorou. "Conformational Study of Select GPR119 Receptor Ligands," College of Sciences Research Conference, University of Texas San Antonio, San Antonio, TX (October 2016)

  • Sarah Kowalski and Evangelia Kotsikorou. "Conformational Study of Select GPR119 Receptor Ligands," 7th Annual PACE Bioethics Conference, University of Texas Rio Grande Valley, Edinburg, TX (April 2016)

  • Tevin Luna and Evangelia Kotsikorou. "Leoidin: A Potential New Antiviotic Against P. Aeruginosa," 7th Annual PACE Bioethics Conference, University of Texas Rio Grande Valley, Edinburg, TX (April 2016)

Current Courses

CHEM 1111 21 - General Chemistry I Lab:
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CHEM 7103 01 - Seminar III:
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CHEM 7101 01 - Seminar I:
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CHEM 3304 02I - Physical Chemistry I:
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CHEM 3304 01I - Physical Chemistry I:
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CHEM 7102 01 - Seminar II:
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CHEM 7301 01 - Thesis II:
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Previous Courses